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Small structures: a yolk shell composite nanoreactor co loaded with Fe3O4 / ZnPc catalyzes the production of ROS for efficient cancer treatment

wallpapers Cruise 2020-12-02

Fe3O4 nanoparticles have Fenton like catalytic effect can autocatalyze hydrogen peroxide (H2O2) to produce hydroxyl radical (· oh) with high toxicity. Because of its strong metabolic activity tumor cells significantly increase the level of H2O2. High level of H2O2 can produce more · Oh under the catalysis of Fe3O4 nanoparticles which can significantly inhibit tumor. Yolk shell composite nanoreactor has a wide application prospect in the field of drug delivery due to its high drug loading efficiency easy surface modification. Previous studies have focused on the magnetic resonance imaging of the system but few reports have been reported on the generation of · Oh as a nanoreactor. At the same time the efficacy of this kind of composite nanoreactors in vivo still needs further research. Based on this Professor Zhao Yanli of Nanyang Polytechnic University of Singapore cooperated with Professor Luo Zhong of Chongqing University to construct a yolk shell composite nanoreactor with Fe3O4 as the core mesoporous MgSiO3 as the shell( YSN@ZnPc@HA )The cavity is loaded with ultra-small Fe3O4 nanoparticles ZnPc photosensitizer the shell of MgSiO3 is modified with hyaluronic acid (HA). Ha can promote the composite nanoreactor to target recognize tumor cells. ZnPc can generate ROS under the excitation of photosensitizer then Fenton react with Fe3O4 nanoparticles to produce highly toxic hydroxyl radicals which can effectively kill tumor cells (as shown in Figure 1).

in order to verify the inhibitory effect of Fe3O4 / ZnPc composite nanoreactor on tumor cells in vitro in vivo confocal microscopy flow cytometry were used to verify the ability of the composite nanoreactor to produce · Oh in tumor cells in situ cell viability assay xenograft tumor model were used to verify its tumor inhibitory effect. This kind of composite nanoreactor can efficiently load hydrophobic ZnPc its surface is easy to modify tumor targeting molecules such as hyaluronic acid. The reactor can selectively target CD44 overexpressed tumor cells effectively perform MRI in tumor sites. Tumor acid environment can also effectively promote Fenton reaction of Fe3O4 / ZnPc composite nanoreactor which can transform H2O2 of tumor cells into · Oh with high cytotoxicity. At the same time the loaded ZnPc produces singlet oxygen under laser irradiation which makes the intracellular ROS level rise above the cytotoxicity threshold thus significantly inhibiting the proliferation of tumor cells tumor growth which provides enlightenment for the further development of multi-functional nanosystems with high cancer therapeutic performance. The article was published on small structures (DOI: 10.1002/sstr.202000065).


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