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Small: application of electrochemical microsensor based on molybdenum sulfide phase regulation mechanism in early warning of prostate cancer

wallpapers Cruise 2020-07-27

prostate cancer is one of the common cancers that endanger men's health. With the aging of population the change of lifestyle the incidence rate of prostate cancer in China is increasing. Prostate cancer is different from most malignant tumors. The growth rate of cancer cells is slow there are no obvious symptoms in the early stage. Once symptoms appear it may be in the middle late stage it is easy to miss the best period of treatment. Therefore it is necessary to develop high-sensitivity prostate cancer early detection technology early screening of high-risk groups in order to improve the survival rate of patients. Compared with the traditional diagnostic methods electrochemical microsensor has the advantages of noninvasive rapid cheap less sample dem. Zhang Yuan his team from the Institute of materials genomics engineering Shanghai university can print electrochemical microsensor chips in batch consistently by using screen printing technology. The micro sensor chip can detect biomolecules in blood or urine only 5 ml sample is needed for each detection. In order to achieve a simple reliable rapid detection of prostate cancer markers the development of sensor interface with good selectivity high sensitivity will help to improve the analysis detection ability of electrochemical chip.

ultra-thin two-dimensional molybdenum sulfide (MoS2) is a kind of graphene material which has abundant catalytic active sites good biocompatibility. It can be used as an ideal building block to construct high-performance sensing materials. Because the electrical properties of MoS2 are closely related to its crystal structure MoS2 in 2H phase is usually semiconductor while MoS2 in 1t phase shows strong metallicity. Zhang Yuan of Institute of materials genomics engineering Shanghai University Tongji Hospital Affiliated to Tongji University Case Western Reserve University of the United States Xianhuang Institute of technology lakar Pradesh Thail Shanghai Institute of Microsystem information technology Chinese Academy of sciences have used density functional theory (DFT) simulation electrochemical tests to verify that 2h-mos2 with semiconductor properties is suitable for prostate cancer The specific marker AMACR (α - methylacyl COA racemase) is an ideal electrochemical sensitive material for detection. However it is difficult for two-dimensional ultra-thin MoS2 materials to exist independently for a long time. Platinum (PT) nanopillar arrays were grown in situ on the surface of the materials to construct three-dimensional ordered structure (PT NWS) array@MoS2 )At the same time the unique structure high aspect ratio of the nanorod array can also provide more effective material electron transport channels for the molecules to be measured. PT NWS array@2H-MoS2 Composite materials are the key sensitive materials. The chip electrochemical sensor can be used to detect AMACR with high sensitivity specificity. The team found that the detection limit of the electrochemical microsensor can be as low as 0.5 pg / μ L it can detect AMACR in the concentration range of PG / μ l to ng / μ l even in the fetal bovine serum environment with complex components. The electrochemical microsensor can detect 23 samples from 26 serum samples of prostate cancer patients. Using micro electrochemical sensor to detect the specific prostate cancer marker AMACR with high sensitivity can detect the signs of lesions in the early stage of cancer which is helpful to realize the early detection treatment of prostate cancer has the advantages of non-invasive convenient cheap. The results are published in small( doi.org/10 1002 / smll. 202000307).

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